关键词: 结核, 肺, 抗药性, 细菌, 博州

Abstract: Objective  To investigate the drug resistant status of pulmonary tuberculosis patients in Bortala Mongolia Autonomous Prefecture (hereafter referred as Bozhou). Methods  A total of 358 cases of PTB, including male 225 cases, female 133 cases, with the mean age of (50±20) years old, registered from January 1 to December 31 of 2013 in Bozhou(include Bole city, Jinghe county, Wenquan county) were enrolled in the investigation, among which, 192 cases were smear positive pulmonary tuberculosis patients(154 cases of initial treated patients, 38 cases of retreatment patients), 166 were smear negative patients. All patients received sputum smear and culture. All culture positive cases recieved eight kinds of drug sensitivity tests(four kinds of the first-line drugs including INH, RFP, EMB, Sm and four kinds of the second-line drugs, including Ofx, Am, Km, Cm). The descriptive and Chi square test were used for statistical analysis of the drugs susceptible results. P<0.05 is considered significant difference. Results  The first line drug resistant rate of patients with tuberculosis bacillus culture positive was 24.60% (46/187), this rate for initial treatment patients and retreatment patients was 22.81%(39/171) and 43.75%(7/16) respectively. Multidrug-resistant rate was 8.02%(15/187), that of the initial treatment patients was 5.26%(9/171) and the retreatment patients was 37.50%(6/16). The second line drug resistant rate was 5.35%（10/187）,for the initial treatment patients was 4.68%（8/171）and 12.50%（2/16） for the retreatment patients. The drug resistant rate of tuberculosis isolates vary with different characteristics. The drug resistant rate of male, female was 26.13%（29/111）, 26.32%（20/76） respectively, and age below 30 years old group, 30- years old group, above 60 age group was 26.19%（11/42）, 27.03%（20/74）, 25.35%（18/71） (χ² values were 0.0005, 0.03, P>0.05) respectively. The top five resistant drugs of eight kinds of antituberculosis drugs were Sm 19.79% (37/187), INH 14.44% (27/187), RFP 10.70% (20/187), Ofx 5.35% (10/187) and EMB 3.21% (6/187). Conclusion  The overall drug resistance situation of Bozhou is very serious. We should focus on epidemic trend of the multidrug resistant tuberculosis and establish dynamic monitoring of drugs resistant level continuously in order to provide theoretical support for prevention and control of multidrug-resistant tuberculosis.

Key words: Tuberculosis, pulmonary, Drug resistance, bacterial, Bortala mongolia autonomous prefecture